Identification of Potentially Therapeutic Target Genes of Hepatocellular Carcinoma
نویسندگان
چکیده
منابع مشابه
DNA methylation of tumor suppressor genes in hepatocellular carcinoma
The basic unit of chromatin is a nucleosome included an octamer of the four core histones and 147 base pairs of DNA. Posttranslational histones modifications affect chromatin structure resulting in gene expression changes. CpG islands hypermethylation within the gene promoter regions and the deacetylation of histone proteins are the most common epigenetic modifications. The aberrant patterns of...
متن کاملHigh-resolution mapping of copy number aberrations and identification of target genes in hepatocellular carcinoma.
Hepatocarcinogenesis involves complex combinations of molecular events, such as genetic aberrations, epigenetic changes, and alterations in gene expression. To elucidate the mechanism of hepatocarcinogenesis, it is necessary to reconstruct these molecular events at each level. This article presents a review of copy number analyses of hepatocellular carcinoma (HCC) using traditional comparative ...
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PURPOSE Hepatocellular carcinoma is the most common primary malignancy of the liver and accounts for as many as one million deaths annually worldwide. The present study was done to identify new transmembrane molecules for antibody therapy in hepatocellular carcinoma. EXPERIMENTAL DESIGN Gene expression profiles of pooled total RNA from three tissues each of moderately differentiated and poorl...
متن کاملIdentification of the typical miRNAs and target genes in hepatocellular carcinoma.
The aim of the present study was to identify miRNAs that were differentially expressed in hepatocellular carcinoma (HCC) by comparing normal and cancer tissue samples and to analyze the correlation of the target genes and HCC. The gene expression profile of GSE31383 was downloaded from the Gene Expression Omnibus database, including 19 samples, 9 normal and 10 from HCC tissue samples. The diffe...
متن کاملIdentification of typical miRNAs and target genes in hepatocellular carcinoma by DNA microarray technique.
OBJECTIVES The purpose of this study was to identify featured miRNAs of hepatocellular carcinoma (HCC) by comparing normal and cancer cell line samples and find potential utility as biomarkers for early diagnosis and treatment of HCC. MATERIALS AND METHODS We downloaded the gene expression profile GSE41077 from Gene Expression Omnibus database which included 6 HCC cell lines samples and 2 con...
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ژورنال
عنوان ژورنال: International Journal of Environmental Research and Public Health
سال: 2020
ISSN: 1660-4601
DOI: 10.3390/ijerph17031053